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Mucolytics Side Effects. What are the side effects of mucolytics? [9][12]increased blood pressure, respiratory distress, chest pain, fever, rectal bleeding, headache, hypotension, lethargy, and skin allergy reportedly occur in less than 5% of cases.

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Mucolytics may cause gastrointestinal irritation and allergic reaction. See the section on nebulisers for more information. One is typically advised to contact a physician if these problems occur, while drowsiness, nausea, and fever are sometimes possible.